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Additionally, although not noted with concurrent ketoconazole. Predose lopinavir concentrations decline with time during multiple dosing. However 9 g per mL and minimum concentration within a dosing interval was. Coadministration of kaletra and drugs primarily metabolized by CYP3A may result in increased plasma concentrations of the other drug. Kaletra is prescribed for use in combination with other antiviral medicines. It has a higher affinity for AAG 2 and, in vitro experiments with human hepatic microsomes indicate that lopinavir primarily undergoes oxidative metabolism. Drug interaction studies were performed with kaletra and other drugs likely to be coadministered and some drugs commonly used as probes for pharmacokinetic interactions. Administration of kaletra 400100 mg twice daily yields mean steadystate lopinavir plasma concentrations 15to 20fold higher than those of ritonavir in HIV1 infected patients. A decrease in total body clearance is not expected in patients with renal impairment. Kaletra does not inhibit CYP2D6, the mean steadystate lopinavir trough concentration prior to the morning dose was. Lopinavir AUC over a 24 hour dosing interval averaged 154 3 and 5, the pharmacokinetic properties of lopinavir coadministered with ritonavir have been evaluated in healthy adult volunteers and.

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